Unravelling microglia-specific contributions to neuronal network activity: Engineering a human stem cell-derived tri-culture on microelectrode arrays
Annika Mordelt, Imke Schuurmans, Caroline Knorz, Dirk Schubert, Nael Nadif Kasri, Lot de Witte · FENS Forum 2024
Neuronal development and function is regulated by a complex interplay between neurons and glial cells. Microglia are the tissue-resident immune cells of the central nervous system bridging immunological and neuronal activity. In recent years, the involvement of microglia in a variety of neurological and psychiatric disorders has been increasingly highlighted. However, understanding microglia-specific contributions to neuronal activity in humans remains challenging. A promising tool to gain mechanistic insight into how microglial cells shape neuronal networks and their activity is combining mic
ePoster · Neuroscience