Development of an organ-on-chip platform for the co-culture of mouse organotypic brain slices with endothelial cells
Tando Maduna, Yasin Ilgaz, Atocha Guedán, Ciro De Luca, Assunta Virtuoso, Giovanni Cirillo, Alan Morin, Julia Sepulveda Diaz, Michele Papa, Fivos Panetsos, José Pérez-Rigueiro, Andreas Vlachos · FENS Forum 2024
Organ-on-chip (OoC) technologies are designed to mimic natural structure and function of organs. Integrating microfluidics to OoCs allows long-term perfusion and stability, essential for cultivating physiological conditions similar to intact organs. However, current OoC systems predominantly use primary cell cultures over organotypic tissue cultures (OTCs) or entire organs, due to the absence of extensive microvasculature. This limitation compromises the viability of larger tissue volumes as they suffer from inadequate oxygen and nutrient delivery, along with the absence of perfusion. This stu
ePoster · Neuroscience