Single administration of focused ultrasound-mediated blood-brain barrier opening is antidepressant with Claudin-5 remodeling
Moshe Willner, Briana K. Chen, Rebecca L. Noel, Alec J. Batts, Alessia Mastrodonato, Michelle Jin, Robin Ji, Louise C. Matthews, Fotis Tsitsos, Daniella Jimenez, Samantha L. Gorman, Clay O. Lacefield, Elisa E. Konofagou, Christine A. Denny · FENS Forum 2024
Major depressive disorder (MDD) is a leading cause of disability worldwide, but its pathogenesis is unclear. Mounting evidence implicates the loss of blood-brain barrier (BBB) integrity as it exposes the brain to harmful inflammatory mediators, antibodies, and serum proteins, but to date no pharmacotherapies specifically target the BBB. Focused ultrasound (FUS) is a non-invasive, neuromodulatory strategy that transiently opens the BBB (FUS-BBBO) when coupled with microbubbles. Here, we examine FUS-BBBO as an independent therapy in a mouse model of stress-induced depression. Briefly, adult male
ePoster · Neuroscience