Topic: FUS P525L

HuD is an RNA-binding protein encoded by the ELAVL4 gene, which is expressed in the nervous system and plays a crucial role during nervous system development. However, recent evidence suggests its potential involvement in neurodegenerative processes, including Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease characterized by death of motoneurons (MNs). Notably, upregulation of both mRNA and protein levels of HuD has been observed in MNs derived from FUS P525L human induced pluripotent stem cells (hiPSCs) and in a Fus-Δ14 knock-in mouse model, impacting on MNs’ transcriptome and