Investigating and modulating κ-opioid receptor G-protein signaling
Ana Lechuga, Julia Baumann, Sarah Seidel, Olga Trovato, Mitja Amon Posch, Moritz Henninger, Michiel Langeslag, Leandra Abt, Marita Baur, Germana Thaler, Teresa Kaserer, Andreas Lieb · FENS Forum 2024
The к-Opioid receptor (OPRK) belongs to the family of G-protein coupled receptors (GPCRs), is mainly localized at axon terminals in different brain regions, and is involved in e.g., nociception, consciousness, or mood. Like all GPCRs, OPRK mediates downstream signaling via e.g. heterotrimeric G proteins, consisting of Gα-, Gβ-, and Gγ-subunits, or β-arrestins. OPRK is reported to primarily signal via the inhibitory Gαi/o family and also exhibits interactions with Gα12, however, how OPRK mediates this preference has not yet been elucidated.In this project we therefore aim to explore the molecul
ePoster · Neuroscience