Topic: G protein-coupled receptor

The serotonin 5-HT6 receptor (5-HT6R) is a G protein-coupled receptor only expressed in the central nervous system. It is a promising target for treating cognitive deficits observed in neurodevelopmental diseases, such as autism spectrum disorders (ASD). Our team has demonstrated a crucial role for the 5-HT6R in neurodevelopment. It participates in neuronal migration, the initiation of neurite growth and dendritic arborization, through interactions with different protein partners. We also confirmed that this receptor is mainly expressed in the primary cilium of neurons and astrocytes, except f

Metabotropic glutamate receptor 2 (mGlu2) is a G protein-coupled receptor expressed in the central nervous system and canonically coupled to Gi/o protein. mGlu2 receptor is the main target of a new generation of antipsychotics which showed unprecedent efficiency on negative and cognitive symptoms of Schizophrenia, which were so far resisting to actual antipsychotics. However, the molecular mechanisms regulating the antipsychotic properties of mGlu2 receptor stimulation remain unclear. In a recent interactomic screen (Philibert et al., Science Advances, 2024), we demonstrated that endogenous mG