Uncovering the role of RTTN in developing brains: Insights from a human brain organoid model
Adva Hadar, Kalina Draganova, Bidisha Bhattacharya, Magdalena Goetz, Orly Reiner · FENS Forum 2024
Microcephaly is a disease in which the head circumference and brain volume decrease. Patients with microcephaly show a range of cognitive deficits. One of the causes of microcephaly is mutations in the RTTN gene. RTTN mutations are responsible for syndromic malformations of cortical development. Here we have generated on-chip human brain organoids and 3D-hippocampal organoids to study the role of RTTN in the developing human brain.A RTTN homozygous pathogenic mutation was introduced in human embryonic stem cells using CRISPR/Cas9 genome editing. The developing control on-chip brain organoids e
ePoster · Neuroscience