Effects of erythropoietin (EPO) on the transcriptome of the oligodendrocyte lineage
Vinicius Daguano Gastaldi, Liu Ye, Yasmina Curto, Anne-Fleur Wildenburg, Xuan Yu, Martin Hindermann, Klaus-Nave Nave, Hannelore Ehrenreich · FENS Forum 2024
Erythropoietin (EPO), a potent growth factor, named after its role in erythropoiesis, has been shown to not only be produced in the brain, but also to have significant effects in improving cognitive performance. The mechanisms by which EPO acts are yet to be fully explored, including the transcriptome changes elicited by it in the oligodendrocyte lineage. Here we explore these changes after a 3-week EPO/Placebo treatment using single-nuclei RNA sequencing. A total of 12.043 nuclei were classified into 5 cell types (oligodendrocyte precursor cell – OPC, committed oligodendrocyte precursor – COP
ePoster · Neuroscience