Alterations in synaptic and excitability properties of basolateral amygdala neurons in APP/PS1 AD mice
Juliana Gonzalez-Sanmiguel, Loreto San Martin, Scarlet Gallegos, Nicolas Riffo-Lepe, Paulina Saavedra, Luis G. Aguayo · FENS Forum 2024
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by early non-cognitive dysfunctions. Recent studies have reported synaptic alterations in limbic circuits in AD animal models, even before amyloid plaque appearance. The basolateral amygdala (BLA) is a critical region of the limbic system involved in diverse emotional processing, and studies in human and AD animal models have reported that it is altered in early AD. However, whether synaptic and excitability properties are altered in the BLA in AD has not been studied. In this study, we used 6-month-old APP/PS1
ePoster · Neuroscience