Investigation of GABAergic system in treatment-resistant depression-related cognitive decline in different age
Chi-Wei Lee, Yang Tzu-Jung, Chi Hsiang, Wu Ching-Yao, Chia Shu-Jui, Li Cheng-Ta, Lin Hui-Ching · FENS Forum 2024
Treatment-resistant depression (TRD), which refers poor responses to adequate antidepressant treatment, have prominent cognitive impairment. Moreover, the depression patients with cognitive impairment could be a risk factor for dementia following aging. The lower aminobutyric acid type A receptor (GABAAR)-mediated activity and GABAB receptor (GABABR)-mediated activity was observed in prefrontal cortex (PFC) of patients with depression. Furthermore, the concentrations declined of both GABA in the PFC following the aging and at beginning of the mid-age has been found, suggesting the GABAergic sy
ePoster · Neuroscience