Topic: GABAergic inhibitory synapses

Neuroligin-2 (Nlgn2) is a postsynaptic adhesion protein that regulates the organization of GABAergic inhibitory synapses. NLGN2 gene variants have been linked to several psychiatric disorders, and deletion of Nlgn2 in mice results in a pronounced increase in innate anxiety-related avoidance behaviors. It is unknown, however, whether Nlgn2 also regulates other forms of defensive behaviors, and through which neuronal circuits these effects are mediated. Here, we therefore investigated the consequences of Nlgn2 deletion on the neuronal circuits that control associative fear learning in mice. We f