Topic: GABAergic microcircuits

Serotonin receptors of class 3 (5HT3-R) are the only subtype of serotonin-gated ion channels which allow for fast synaptic transmissions. Within this family, 5HT3A is the predominant subtype. These receptors are thought to be involved learning, memory and neuroprotection and mutations in HTR3A gene is associated with neuropsychiatric disorders. However, a mechanistic understanding of the role of these receptors in learning and memory is not well understood. Using a gene-trap FLP-dependent conditional knock-in and CRE-dependent conditional knock-out mouse model for 5HT3AR, we show that restorat