Nicotine suppresses feeding behavior by exerting opposite effects on the neuronal activity of the arcuate nucleus
José Enrique Ramírez Sánchez, Andrea Mondragon-García, César Sandoval-González, Fabiola Hernández-Vázquez, Salvador Hernández-López, Julieta Garduño · FENS Forum 2024
The arcuate nucleus (ARC) is a significant brain region involved in energy homeostasis, specifically feeding behaviour. It is widely reported that nicotine consumption reduces feeding behaviour and body weight in both humans and rodents. Milleu et al. (2011) demonstrated that nicotine increases the activity of the Pro-opiomelanocortin (POMC) positive cells in this nucleus. Huang et al. (2011) reported that nicotine increases the activity of POMC cells and NPY-positive cells. This finding may seem contradictory as NPY neurons promote hunger signals while POMC neurons generate signals of satiety
ePoster · Neuroscience