Response of neocortical dysplasia to thalamic high-frequency stimulation
Linda Iris Joseph Tomy, Elif Köksal-Ersöz, Anca Nica, Maxime Yochum, Pascal Benquet, Fabrice Wendling · FENS Forum 2024
The therapeutic application of centromedian nucleus stimulation (CMS) has been limited by the lack of knowledge of its mechanism of action. In this study, we used stereoelectroencephalography (SEEG) signals recorded from a patient with epilepsy, caused by focal cortical dysplasia. The recordings revealed frequency-dependent suppression of neocortical interictal discharges linked to the application of CMS. There was no change in neocortical interictal discharges with 50Hz CMS, but with CMS at 70Hz, 100Hz and 150Hz, varying periods of suppression were observed during and/or after stimulation. We
ePoster · Neuroscience