SHANK3 deficiency leads to GABAergic abnormalities and morphological changes in somatostatin-expressing interneurons in olfactory brain regions
Denisa Mihalj, Pirnik Zdeno, Borbelyova Veronika, Bacova Zuzana, Bakos Jan · FENS Forum 2024
Sensory abnormalities, including altered olfaction, represent potential diagnostic criteria for autism spectrum disorder (ASD). Atypical GABAergic neurons have been extensively described in ASD animal models. Olfactory brain regions contain a large subpopulation of GABAergic interneurons that express somatostatin (Sst). However, the role of Sst-expressing interneurons in olfactory processing in ASD remains unclear. In this study we evaluated the mRNA expression of GABAergic synaptic components in the olfactory bulb and frontal cortex, the number of GABAergic postsynaptic puncta in primary olfa
ePoster · Neuroscience