Topic: Gadd45ɑ

Growth Arrest and DNA Damage inducible protein 45 alpha (Gadd45ɑ) is a protein well characterised for its role in DNA demethylation and cell cycle regulation. Behavioural studies showed that Gadd45ɑ-knock-out (KO) in mice impairs long-term memory consolidation following aversive learning tests. Proceeding experiments revealed that Gadd45ɑ is an RNA binding protein (RBP) that post-transcriptionally stabilises synaptic plasticity- and memory-related mRNAs in an activity-dependent manner. This project aims to decode the RNA and protein interaction networks of Gadd45ɑ in mouse hippocampal cells.Me