Topic: Gadolinium infusion

Changes in olfaction are emerging as early warning signs of several major neurological diseases. Neurological diseases are also associated with aberrant brain rhythms. Olfactory sensory neurons (OSN) deliver input from the nasal epithelium (NE) to the olfactory bulb (OB) and are key drivers of rhythmicity. Here, we examine the role of sensory input arising from the NE in the generation of electrophysiological rhythms in the OB. Rats were implanted with electrodes in the OB and post-surgery gadolinium/saline was infused bilaterally to both nares. Olfactory function was assessed using the hidden