Synergistic effects of intranasally administered GALR2 and Y1R agonists on cognitive and mood-related behaviors in adult rats: Implications for neurodegenerative and mood disorders
Manuel Narvaez Pelaez, Isabel Moreno Madrid, Jose Carlos Arrabal Gómez, Pedro Serrano castro, Estela Diaz Sanchez, Jose Erik Alvarez Contino, Miguel Angel Barbancho Fernández, Jose Andrés Sánchez Pérez, Encarnación Blanco Reina, Kjell Fuxe, Dasiel O. Borroto Escuela, Natalia García Casares · FENS Forum 2024
Background: The complexity of neurodegenerative and mood disorders necessitates innovative therapeutic strategies beyond current treatments. This study explores the combined therapeutic potential of Galanin receptor 2 (GALR2) and Neuropeptide Y Y1 receptor (Y1R) agonists, administered intranasally, on spatial memory, antidepressant-like behavior, and neurogenesis in adult rats.Methods: The investigation employed intranasal co-delivery of GALR2 agonist M1145 and Y1R agonist to adult rats, examining spatial memory through the object-in-place task and antidepressant-like effects via the Forced Sw
ePoster · Neuroscience