Smart Glia: Investigating the nervous system plasticity upon cancer
Assunta Virtuoso, Giampaolo Milior, Alesya Evstratova, Julien Moulard, Gilles Huberfeld, Nathalie Rouach, Michele Papa · FENS Forum 2024
High-grade gliomas (HGGs) include astrocytoma and glioblastoma. They are characterized by aggressiveness, intra- and inter-tumor heterogeneity, and infiltrating ability, decreasing the efficacy of resection and therapies. Glioma invasiveness depends on the dynamic interaction between glial cells, mainly microglia, and astrocytes. Accordingly, extra-CNS metastasis remains a rare clinical entity. Astrocytic connexin43 (Cx43) is under microglia control. Cx43-mediated signaling profoundly impacts HGGs invasion and could be a potential target in the glia-HGGs communication. However, it needs furthe
ePoster · Neuroscience