ePoster · Neuroscience
Glucocorticoid signalling affects astrocyte function via long non-coding RNAs
Tarannomsadat Taghavi, Ulrike Fuchs, Susanne Burkhardt, Anna-Lena Schuetz, Farahnaz Sananbenesi, Andre Fischer · FENS Forum 2024
Glucocorticoid signalling serves as a central regulator of the body's stress response and has been associated with several diseases affecting the central nervous system (CNS), such as major depressive disorder or Alzheimer’s disease. While the cell type-specific effect of glucocorticoids in the CNS has been studied previously, our understanding of how glucocorticoids act on astrocytes and their impact on neuronal network plasticity is limited. It's important to note that only 1.5% of the genome encodes proteins, while the remaining 98.5% consists of non-coding RNAs (ncRNAs) implicated in vario