Perinatal methyl donor deficiency increases the prevalence of “depressive-like” behavior in association with alteration of the microbiota-gut-brain dialogue in a transgenerational rat model
Arnaud Michel, Charlène Dauriat, Carine Bossenmeyer-Pourié, Jean-Louis Guéant, Rémy Umoret, Jean-Marc Alberto, Okan Baspinar, Benoit Chassaing, Tunay Kökten, Grégory Pourié · FENS Forum 2024
The prevalence of neurodegenerative diseases like Alzheimer’s or Parkinson’s, and mental disorders like depression or anxiety appears higher in patients with gastrointestinal tract diseases like irritable bowel syndrome and inflammatory bowel disease. Conversely, depressed patients have higher rates of gastrointestinal disorders. Moreover, an altered microbiota, called “dysbiosis” has been reported in both neurological and intestinal diseases, which suggests strong interactions between gut microbes and their host. The emergence of the intestinal microbiota as one of major regulators of gut-bra
ePoster · Neuroscience