Novelty modulates neural coding and reveals functional diversity within excitatory and inhibitory populations in the visual cortex
Farzaneh Najafi,Iryna Yavorska,Marina Garrett,Alex Piet,Peter Groblewski,Anton Arkhipov,Stefan Mihalas,Shawn Olsen · COSYNE 2022
Stimulus novelty modifies perception and promotes exploration and learning. What are the neural circuit mechanisms that underlie the effects of novelty? To address this question, we trained mice on a visual change detection task, while we performed two-photon calcium imaging of neural activity from excitatory and inhibitory (VIP and SST) neuron classes across multiple layers of the visual cortex (areas V1 and LM; 82 mice, 551 sessions, 34,619 neurons). The behavioral task required detecting image changes that occurred amid repeated image presentations. Additionally, flashed images were periodi
Thu, Mar 17, 2022