Topic: Gauss-Newton update rule

Across species, neurons possess numerous ion channel types, with a single cell typically expressing tens of channel genes, which translate to hundreds or even thousands of channel protein types, each with different kinetics [1]. Moreover, maximal conductance densities across individuals are also highly variable and subject to neuromodulators which are essential for enabling the nervous system to switch between behaviorally relevant modes [2,3]. This raises the question of how neuromodulators can reliably induce changes in intrinsic neuronal properties across a heterogeneous population. At th