Topic: GC assemblies

Memories associating personal experiences and places can be recalled after extended periods of life-time. Despite the current prevailing view that episodic memories are fully allocated to cortical areas after an initial encoding phase within the hippocampus, lesion studies suggest that memories might be partially retained within the hippocampus. We hypothesize that sparsely active and spatially tuned dentate gyrus granule cell (GC) assemblies efficiently store and retrieve episodic memories over extended live spans.We employed two-photon in vivo calcium-imaging of somata and mossy-fiber bouton