ePoster · Neuroscience
Effects of AAV-GDNF and AAV-GDF5 in an AAV-α-synuclein rat model of Parkinson’s disease
Fionnuala Wilson, Martina Mazzocchi, Louise Collins, Gerard O'Keeffe, Aideen Sullivan · FENS Forum 2024
Parkinson’s disease (PD) is characterised by midbrain dopaminergic neuron degeneration resulting from intraneuronal a-synuclein (aSyn) accumulation. Adeno-associated virus (AAV)-mediated delivery of neurotrophic factors (NTFs), including GDNF, has been tested in clinical trials and has potential to be used as disease-modifying therapy for PD. We have previously shown that the NTF growth/differentiation factor 5 (GDF5) exerts neuroprotective effects after intranigral delivery in an aSyn rat model of PD. Here we examined whether delivery of GDF5 and GDNF to the striatum (putamen), a more clinica