Topic: gender bias

Autism Spectrum disorders (ASD) exhibit a gender bias where boys are affected predominantly. However, the mechanisms underlying resilience in VPA females are not entirely understood. To shed light on this disparity, we utilized an ASD mouse model, the valproic acid (VPA) model where sociability is more affected in males than females. We hypothesized that immunological mechanisms are involved in the resilience of VPA female mice particularly during the juvenile period because this is when they display unique neuroinflammatory patterns. To tackle this hypothesis, we assessed the impact of juveni