Adaptive decision-making requires RNF10-mediated synapse-to-nucleus signaling
Nicolò Carrano, Ana Ribeiro, Maria Italia, Filippo La Greca, Francesca Genova, Laura D'Andrea, Elisa Zianni, Luisa Ponzoni, Gael Barthet, Stephan C. Collins, Mariaelvina Sala, Nico Mitro, Christophe Mulle, Binnaz Yalcin, Elena Marcello, Gardoni Fabrizio, Monica DiLuca, Diego Scheggia · FENS Forum 2024
Synaptonuclear signalling pathways have been implicated in long term plasticity events. Nonetheless, their role in regulating cognitive behavior remains to be clarified. Here, we demonstrated that RNF10-mediated synapse-to-nucleus signaling, linking activation of synaptic NMDARs to specific transcriptional programmes in the dorsal CA1, is necessary for cognitive flexibility. In vivo RNF10 downregulation, through gene deletion and silencing, induced, specifically in CA1, alterations of both long-term potentiation and dendritic spines’ structure. At behavioral level, RNF10 downregulation suppres