Unraveling the molecular mechanism regulated by Sox9 in cortical neural stem cell behavior and fate commitment
Jaime Fabra Beser, Isabel Mateos-White, David de Agustín-Durán, Alba Marín-Garnes, Carmen M. Mateos-Martínez, Laura Veintimilla-Escot, Santos Franco, Cristina Gil-Sanz · FENS Forum 2024
During mammalian cortical development, how different subtypes of projection neurons are generated by neural stem cells remains a major challenge. Over recent years, the expansion of RNA sequencing technologies has allowed the identification of heterogeneity within the progenitor pool. Understanding how this heterogeneity could participate in the control of cortical fate commitment is an exciting task. Here, we use single-cell RNA sequencing to describe the molecular characteristics of a subpopulation of RGCs that present reduced neurogenic behavior at early embryonic ages to later produce most
ePoster · Neuroscience