Topic: Genetic models

Zebrafish is becoming an increasingly popular animal for modelling seizures and epilepsy. Various pharmacological and genetic models are utilized for both discovering new anti-epileptic drugs and for investigating fundamental mechanisms regulating neural excitability, seizures, and epilepsy. We aimed at developing multiple pharmacologically induced seizure and epilepsy models, in order to utilize these models for high-throughput behavioural screens and for functional brain imaging. We showed that several parameters of locomotor behaviours and spatial exploration are altered in seizure and epil