Improved dual-color GRAB sensors for monitoring dopaminergic activity in vivo
Yizhou Zhuo, Bin Luo, Xinyang Yi, Hui Dong, Xiaolei Miao, Jinxia Wan, John Williams, Malcolm Campbell, Ruyi Cai, Tongrui Qian, Fengling Li, Sophia Weber, Lei Wang, Huan Wang, Yu Zheng, Marina Wolf, Yingjie Zhu, Mitsuko Watabe-Uchida, Yulong Li · FENS Forum 2024
Dopamine (DA) is a crucial monoamine neurotransmitter involved in many physiological and pathological processes through a complex network of dopaminergic projections, and the ability to directly monitor DA dynamics is essential for understanding its physiological functions. Despite the widespread use of genetically-encoded dopamine fluorescent sensors in vivo, the detection of DA is often limited to highly innervated regions. Consequently, cortical DA detection has received comparatively little attention due to a lake of sensitivity of current generations of sensors. To address this gap, we ha
ePoster · Neuroscience