Topic: genetically encoded fluorescent reporters

Stress-related psychiatric disorders have been associated with polymorphisms in the gene encoding FK506-binding protein 5(FKBP5), a co-chaperone of the glucocorticoid receptor(GR). Stress response is coordinated by the hypothalamic-pituitary-adrenal(HPA) axis, through secretion of glucocorticoids(GC). Additionally, the HPA is a site of convergence of the circadian clock and the stress response systems. Physiologically, GCs act as molecular effectors of circadian rhythm that synchronize transcriptional and metabolic activity in peripheral tissues. However, not much is understood about the analo