Navigating the challenges of investigating the influence of gestational gut microbiome disruption and perinatal asphyxia on neurodevelopmental reflexes in rat offspring
Ana Maria Catrina, Mara Ioana Ionescu, Cerasela Haidoiu, Vladimir Suhaianu, Ioana Alexandra Dogaru, Didina Catalina Barbalata, Cristian Ciotei, Vlad Morozan, Tasnim Chazli, Mara Belcin, Ana-Maria Zagrean · FENS Forum 2024
The gestational gut microbiota exerts significant influence on infant neurobehavior and postnatal brain resilience. This study addresses challenges encountered in assessing the effects of gestational antibiotic administration (GAA) and perinatal asphyxia (PA) on offspring neurodevelopmental reflexes.A preliminary study evaluated the effects of an initial antimicrobial cocktail (GAA-1) and PA on Wistar rat offspring. GAA-1 was initiated on gestational day 11 using a cocktail comprising ampicillin, vancomycin, neomycin, clindamycin, and amphotericin-B, followed by PA exposure on postnatal day (P
ePoster · Neuroscience