Neural mechanisms encoding gestational immune activation in the female brain
Laura Cuenca Rico, Anna Gundacker, Barbara Czuczu, Kira Schimmel, Lukasz Piszczek, Wulf Haubensak, Igor Adameyko, Daniela Pollak · FENS Forum 2024
Gestational infection is considered as contributing factor for the development of psychopathologies later in life. The Maternal Immune Activation (MIA) mouse model, based on the systemic administration of the double-stranded RNA analogue Poly(I:C), is used to study the effects of gestational infection on offspring brain function and behavior.Previously, we demonstrated that stimulating pregnant mice with Poly(I:C) not only affects the developing brain in-utero, but also impacts on the structural and functional integrity of the maternal brain to disrupt maternal care behavior postpartum. Howeve
ePoster · Neuroscience