Simple Limbal Epithelial Transplantation (SLET): Therapeutic efficacy in a limbal stem cell deficiency (LSCD) mouse model
Nicola Piazza, Stefania Zorzin, Andrea Corsi, Sissi Dolci, Francesca Ciarpella, Marzia Di Chio, Erika Bonacci, Emilio Pedrotti, Ilaria Decimo · FENS Forum 2024
Limbal Stem Cell Deficiency (LSCD) is a pathologic condition resulting from the dysfunction and/or an insufficient quantity of limbal epithelial stem cells (LESC) characterized by conjunctivalization, neovascularization and stromal scarring. Recently, Simple Limbal Epithelial Transplantation (SLET) was reported as reproducible, innovative technique for corneal regeneration and vision restoration for patients with LSCD. However, the regenerative potential of the transplanted cells in corneal healing is not fully understood. Therefore, we set up and validate an in vivo mouse model of LSCD and in
ePoster · Neuroscience