Topic: GI254023X

Development of pro-neurogenic therapies for compensating the neuronal loss and restoration of degenerated synaptic networks in neurodegenerative diseases has been difficult to achieve, which calls for new strategies to promote adult neurogenesis and counteract neurodegeneration. BRI2 is a ubiquitously expressed transmembrane protein that undergoes proteolytic processing, resulting in the formation of several secreted peptides. The precise physiological function of BRI2 remains elusive, however preliminary results suggested an increase in BRI2 levels during neuronal development, and a strong ph