Aberrant neuronal activity and habituation of the giant fiber escape response circuit in Drosophila NF1 mutants: A pharmacogenetic approach
Efthimios Skoulakis, Eleni Giannopoulou, Kalliopi Atsoniou, Eirini-Maria Geogranta · FENS Forum 2024
Neurofibromatosis type 1 (NF1) is a genetic disorder caused by reduction or absence of neurofibromin due to mutations in the NF1 gene that result in multiple behavioral defects among other aberrant phenotypes. To directly assess the consequences of Nf1 deficiency on evoked neuronal activity, potentially underlying neuroplasticity defects, we utilized null mutations, point mutations, and RNA interference to manipulate Nf1 levels in Drosophila melanogaster. Our study focused on assessing the functional alterations in the giant fiber system, a well-established electrophysiological model to study
ePoster · Neuroscience