Topic: glia cell-derived neurotrophic factor

Absence Seizures (AS) are sudden, non-convulsive seizures characterised by altered consciousness, behavioural arrest and 3-4 Hz spike-and-wave discharges on the ictal EEG [3]. ASs have a significant impact on the quality of life due to the risk of injury and neuropsychiatric comorbidities, such as impairments in emotional, cognitive, memory and linguistic abilities [1,5]. Moreover, cognitive impairments have been described in Genetic Absence Epilepsy Rat from Strasbourg (GAERS) rats, which is a well characterized ASs animal model [8]. Recent evidence shows that glia cell-derived neurotrophic f