Topic: glial calcium wave

Evading threats relies on deploying complex avoidance strategies such as deciding between escape and motor arrest. Although studies across vertebrates indicate that the brainstem is critical for motor arrest, the mechanisms remain elusive. A recent study in zebrafish showed that upon sensory-motor mismatch, passivity involves noradrenergic signaling eliciting a brain-wide glial calcium wave. However, it remains unknown how noradrenergic activation translates into subsequent glial calcium waves and provokes motor arrest. Our working hypothesis is that noradrenergic neurons integrate intensive s