The effect of vitamin D deficiency and unpredictable chronic mild stress on memory and hippocampal plasticity in middle-aged mice
Külli Jaako, Kelli Somelar-Duracz, Monika Jürgenson, Janeli Viil, Alexander Zharkovsky · FENS Forum 2024
Vitamin D deficiency (VDD) is a worldwide problem, especially among the elderly and epidemiological studies have found a link between VDD, cognitive decline and depression. However, it is unclear whether VDD directly drives the development of depression and cognitive decline or whether it is secondary to co-occurring pathology.In this study, we sought to determine whether long-term VDD causes memory impairments and depressive-like behavior alone or in combination with chronic stress and to elucidate co-occurring dysfunctions in neuronal and glial plasticity in the dentate gyrus (DG) of the hip
ePoster · Neuroscience