Topic: glioblastoma cells

Our investigation delves into the intricate interplay between adult hippocampal neurogenesis, a pivotal constituent of long-term memory, and its susceptibility to stress. The ongoing hypothesis is that stress, by impeding neurogenesis, contributes to symptoms associated with post-traumatic stress disorder (PTSD). Our work explores the potential of delta-9-tetrahydrocannabinol (THC), the psychoactive constituent of cannabis, in mitigating stress-induced gene expression alterations in astrocytes, thereby fostering neurogenesis. The initial phase involves inducing cellular stress in an astrocyte-