Topic: gliosis culture model

While several studies have presented evidence that both mouse and human adult cortical astrocytes can dedifferentiate and form multipotent neurospheres after brain injury, other observations support that these neurospheres are formed by astroglia progenitors derived from subependymal zone (SEZ) resident neural stem cells which migrated to the cortex. In this study, we developed a new gliosis culture model composed by cells from the injured cortex, including reactive astrocytes, microglia, macrophages, and NG2 cells that mimic some characteristics of the injured brain but in a more controlled l