Impact of single gene mutation on circuit structure and spontaneous activity in the developing cortex
Zhuoshi Liu,Jan Hendrik Kirchner,Juliette Cheyne,Christian Lohmann,Julijana Gjorgjieva · COSYNE 2022
Understanding how neural circuits in the brain wire up during development is important for the implementation of numerous functions in adulthood, but also for the prevention and treatment of many neurological disorders that result from bad wiring. Before the onset of sensory experience, spontaneous activity in the developing brain organizes and refines circuits. Hence, alterations in spontaneous activity can lead to severe deficits in wiring. One such alteration occurs in the Fragile X mouse model, where a single genetic mutation reduces cortical inhibition and increases the number of neurons
Thu, Mar 17, 2022