Topic: Glucagon-Like peptide 1

Hedonic overeating is usually derived from overriding homeostatic food intake (FI) and is thought to be mainly responsible for modern age obesity. Glucagon-like peptide 1 (GLP-1) is a major signal of reaching energy balance and satiety, having a major role in normal FI behaviour.We investigated the effects of the GLP-1 agonist exenatide on palatability-driven feeding regulation in adult male rhesus macaques (n=5) using a novel operant FI paradigm. In each session, one of two available food pellets with different palatability values was offered as meal in all combinations with two daily feeding

Aims: α-synuclein is a protein that is highly expressed in brain neurons. Its normal function is still unknown, but it is thought to be crucial to the onset of dementia with Lewy bodies (DLB). As of now, DLB cannot be sufficiently explained by mutations in the α-synuclein protein because there are so few α-synuclein mutations found in DLB. Nevertheless, several studies have revealed that individuals with DLB also co-exhibit Aβ accumulation in the brain, suggesting that Aβ could be involved in α-synuclein neurotoxicity. However, the exact molecular mechanism behind Aβ-induced α-synuclein toxici

Alcohol use disorder (AUD) is a complex and severe neuropsychiatric disorder with high mortality and morbidity rates. Insight into the complex mechanisms that underlie alcohol-related responses would contribute toward novel treatment options for AUD. Glucagon-like peptide 1, a gut brain peptide that regulate appetite, has lately been suggested as such candidate. The GLP-1 receptor agonist, exendin-4 (Ex4), prevents alcohol-induced reward, alcohol intake, relapse drinking and the motivation to consume alcohol in rodents. However, the brain circuits that participate in the ability of GLP-1 to re