Topic: glucocorticoid hormones

Cognitive and social deficits are core to most psychiatric diseases. Dysfunctional connectivity in brain networks, including the prefrontal cortex (PFC) and its interacting subcortical structures, is supposed to elicit these deficits. Stress exposure and the ensuing release of glucocorticoid hormones is a common risk factor for psychiatric diseases and is known to modulate cognitive function partly through its binding to its receptor GR. The general aim of this work is to study the impact of stress exposure on PFC function and its extended brain networks. As expected, we show here that repeate