Insulin signaling in astrocytes plays a role in brain-liver axis in the control of glucose production
Elena Garcia Clave, Ismael González García, Heiko Backes, Ignacio Torres Alemán, Jessica Yue, Cristina García Cáceres · FENS Forum 2024
Insulin plays a central role in glycaemic control, extending its regulatory influence beyond peripheral organs to the brain. Elevated circulating insulin levels, indicative of insulin resistance, are a hallmark of obesity and type 2 diabetes. Traditionally, the brain was thought to be insensitive to insulin, but our findings show that non-neuronal cells, specifically astrocytes located at the interface of neurons and blood vessels, sense and respond to insulin, thereby influencing systemic glucose control. Intrigued by these discoveries and recognising the potential of targeting these cells to
ePoster · Neuroscience