Topic: glucose hypometabolism

To survive in harsh environment such as food shortages in cold seasons, some animals develop a specific physiologic state—the hibernation. Recently, a hibernation-like state was successfully induced in non-hibernators such as mice. This state is induced by activation of Qrfp neurons in the preoptic area of the hypothalamus and is called Q-neuron-induced hypothermia and hypometabolism (QIH) (Takahashi et al., Nature, 2020). The mice showed hypothermia with very low systemic oxygen consumption during QIH. However, it remains unclear how the metabolism of glucose, the main energy resource, is reg