ePoster · Neuroscience
Extrasynaptic NMDARs activation by co-agonist glycine controls the occurrence of bursts in nigral dopamine neurons
Sofian Ringlet, Laura Caldinelli, Laura Vandries, Vincent Seutin, Kevin Jehasse, Loredano Pollegioni, Dominique Engel · FENS Forum 2024
Dopamine (DA) neurons in the substantia nigra are vital for the control of movement. This fundamental function is encoded by the output signal of DA neurons which switches from spontaneous firing to bursts of action potentials. The latter produces an increase of DA release in targeted areas which is associated to locomotion initiation. The impairment of this process, such as DA neurons degeneration, leads to the motor symptoms of Parkinson’s disease. The activation of the N-methyl-D-aspartate receptors (NMDARs), by the simultaneous binding of glutamate and a co-agonist, is indispensable for th