Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modelling
Tuomo Mäki-Marttunen, Kim T. Blackwell, Ibrahim Akkouh, Alexey Shadrin, Mathias Valstad, Torbjørn Elvsåshagen, Marja-Leena Linne, Srdjan Djurovic, Gaute T. Einevoll, Ole A. Andreassen · FENS Forum 2024
Schizophrenia phenotypes are suggestive of impaired cortical plasticity in the disease, but the mechanisms of these deficits are unknown. Genomic association studies have implicated a large number of genes that regulate neuromodulation and plasticity, indicating that the plasticity deficits have a genetic origin. Here, we used biochemically detailed computational modelling of post-synaptic plasticity to investigate how schizophrenia-associated genes regulate long-term potentiation (LTP) and depression (LTD). We combined our model with data from post-mortem RNA expression studies (CommonMind ge
ePoster · Neuroscience