Altered semaphorin (SEMA3F) levels lead to increased glutamatergic synaptic transmission in temporal lobe epilepsy (TLE)
Vivek Dubey, Arpna Srivastava, Dixit Aparna Banerjee, Manjari Tripathi, Chandra P Sarat, Banerjee Jyotirmoy · FENS Forum 2024
Temporal lobe epilepsy (TLE), the most common form of DRE, is associated with enhanced glutamate receptor-mediated hyperexcitability in the temporal lobe structures. The mechanism of regulation of aberrant glutamatergic activity in TLE is still elusive. Sema 3F regulates the AMPA receptor surface expression in post-synapse. In this study, we investigated the contribution of semaphorin3F (SEMA 3F) to glutamatergic synaptic activity in TLE rats' hippocampus and anterior temporal lobe (ATL). synaptic transmission in the hippocampus and ATL. Golgi-Cox staining was conducted to visualize alteration
ePoster · Neuroscience