Topic: glutamate-decarboxylase

GABAergic neurons are produced outside cortical proliferative zones and migrate tangentially into the cortex using various routes, including the marginal zone (MZ). Analyzing Nissl and immunohistochemically processed postmortem brain tissue, we observed that between postconceptional week 15 and 20 in human, and between embryonic day 64 and 75 in the cynomolgus monkey, the width of the MZ doubled and the density of small cells expressing calretinin, calbindin, somatostatin and glutamate-decarboxylase (GAD) increased. We also observed that the major sources of these prospective GABAergic neurons